AJOVY: Uses, Side Effects, Safety and More


What is AJOVY?

Ajovy is a brand name for fremanezumab, which is a medication used for the preventive treatment of migraine headaches in adults. It belongs to a class of drugs known as calcitonin gene-related peptide (CGRP) antagonists. Ajovy works by blocking the activity of CGRP, a molecule involved in the pathophysiology of migraines.


The primary use of AJOVY is for the prevention of migraines in adults. It is not intended for the treatment of acute migraine attacks, but rather for the reduction of their occurrence. AJOVY is typically prescribed for individuals who experience frequent migraines, defined as eight or more migraine days per month.

Common Side Effects of AJOVY

  • Injection site reactions, such as pain, redness, or swelling at the injection site
  • Fatigue or tiredness
  • Constipation
  • Muscle pain or stiffness
  • Itching or rash
  • Nausea
  • Flu-like symptoms, such as fever, chills, or body aches

Rare Side Effects of AJOVY

  • Allergic reactions, including severe rash, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing (anaphylaxis)
  • Hypersensitivity reactions, such as fever, rash, or joint pain
  • Liver problems, indicated by symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or persistent abdominal pain
  • Changes in mood or behavior, such as depression or anxiety
  • Neurological symptoms, such as dizziness, confusion, or seizures
  • Increased risk of infections, although this risk appears to be low
  • Worsening of pre-existing medical conditions, particularly in individuals with certain autoimmune diseases or compromised immune systems

AJOVY Safety for Pregnant Women and Children

The safety of AJOVY for pregnant women and children has not been established. It is recommended that pregnant women avoid using AJOVY unless the potential benefits outweigh the potential risks. Similarly, the use of AJOVY in children has not been studied, and its safety and efficacy in this population are not known.

AJOVY Recall

As of the writing of this article, there have been no recalls of AJOVY reported. However, it is always important to stay informed about any potential recalls by regularly checking with your healthcare provider or the Food and Drug Administration (FDA) for the latest updates.

AJOVY FDA Approval

AJOVY received FDA approval in September 2018 for the preventive treatment of migraines in adults. The approval was based on clinical trials that demonstrated the effectiveness and safety of AJOVY in reducing the frequency of migraines.

Why is AJOVY Prescribed?

AJOVY is prescribed to individuals who have been diagnosed with migraines and experience frequent migraine attacks. By preventing or reducing the occurrence of migraines, AJOVY can help improve the quality of life for these individuals and reduce the need for other medications or interventions.

How Should AJOVY be Used?

AJOVY is administered as a subcutaneous injection once a month. It can be self-administered by the patient or given by a healthcare professional. The injection is typically given in the abdomen, thigh, or upper arm. It is important to follow the instructions provided by your healthcare provider on how to properly use AJOVY.

Other Uses for AJOVY

AJOVY is currently only approved for the prevention of migraines in adults and should not be used for any other purposes unless specifically prescribed by a healthcare professional.

Special Precautions for AJOVY

Before starting AJOVY, it is important to inform your healthcare provider about any medical conditions you may have, especially if you have a history of liver or kidney problems. Additionally, let your healthcare provider know about any other medications you are taking, as AJOVY may interact with certain drugs.

Storage and Disposal of AJOVY

AJOVY should be stored in the refrigerator between 36°F and 46°F (2°C and 8°C). It should not be frozen. If necessary, AJOVY can be kept at room temperature (up to 77°F or 25°C) for up to 24 hours before use. Unused portions of AJOVY should be discarded properly according to local regulations.

In Case of Emergency/Overdose of AJOVY

In the case of an emergency or overdose of AJOVY, it is important to seek immediate medical attention. Contact your healthcare provider or call your local emergency services for assistance.

Other Information about AJOVY

It is important to keep all appointments with your healthcare provider while taking AJOVY. They will monitor your response to the medication and make any necessary adjustments to your treatment plan. If you have any questions or concerns about AJOVY, do not hesitate to reach out to your healthcare provider for clarification.

Is AJOVY Dangerous?

Like any medication, AJOVY carries some risks and potential side effects. However, when used as directed and under the supervision of a healthcare professional, it is generally considered safe and effective for the prevention of migraines in adults. It is important to discuss any concerns or questions you may have with your healthcare provider before starting AJOVY.

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